Drug Target Could Help Fight Gum Disease

Stripping certain oral bacteria of their access key to gangs of other pathogenic oral bacteria could help prevent gum disease and bone loss. A study published in the journal Microbiology suggests that this bacterial access key could be a drug target for people who are at high risk for developing gum disease. The bacteria Treponema denticola frequently gangs up in communities with other pathogenic oral bacteria to produce destructive dental plaque. Researchers from the University of Bristol have discovered that a molecule on the surface of T denticola called Treponema denticola chymotrypsin-like ptoteinase (CLTP) acts as the key pass that grants the bacterium access to the community by allowing it to latch onto the oral bacteria. Once incorporated, CLTP, can start to wreak havoc by inhibiting blood clotting (leading to continued bleeding of the gums) and causing tissue destruction. Professor Howard Jenkinson, who led the study, said that, “Devising new means to control these infections requires deeper understanding of the microbes involved, their interactions, and how they are able to become incorporated into dental plaque.”

The study shows that CLTP could be a good target from which novel therapies could be developed. He continued, “CLTP gives Treponema access to other periodontal communities, allowing the bacteria to grow and survive. Inhibiting CLTP would deny Treponema access to the bacterial communities responsible for dental plaque which in turn would reduce bleeding gums and slow down the onset of periodontal disease and tooth loss.”

The team is now working to find a compound that will inhibit CLTP. “If a drug could be developed to target this factor, it could be used in people who are at higher risk from developing gum disease,” explained Professor Jenkinson. (Source: Society of General Microbiology, February 7, 2012.) “Preventing bacteria from falling in with the wrong crowd could help stop gum disease.”

ScienceDaily. Retrieved February 9, 2012, sciencedaily.com

Dr. Edward Gottesman Lectured for the New York Academy of Cosmetic Dentistry, November 2011: “Gummy To Glam”
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